I-Glutaraldehyde Technological Frontier: Ukuphumelela ku-Anti-Calcification Technology

Emkhakheni wokufakelwa kwenhliziyo, i-glutaraldehyde sekuyisikhathi eside isetshenziselwa ukwelapha izicubu zezilwane (njenge-bovine pericardium) ukuze kukhiqizwe ama-valve e-bioprosthetic. Kodwa-ke, amaqembu asele e-aldehyde amahhala avela ezinqubweni zendabuko angaholela ekubalweni kwangemuva kokufakelwa, okufaka engozini ukuqina kwesikhathi eside kwemikhiqizo.

Ibhekana nale nselelo, ucwaningo lwakamuva olushicilelwe ngo-Ephreli 2025 lwethula ikhambi lokwelapha eliphikisana nokubala (igama lomkhiqizo: Periborn), elizuza inqubekelaphambili emangalisayo.

1.Ukuthuthukiswa Okubalulekile Kwezobuchwepheshe:

Lesi sixazululo sethula ukuthuthuka okuningana okubalulekile kunqubo yendabuko yokuxhumanisa i-glutaraldehyde:

I-Organic Solvent Cross-Linking:
I-Glutaraldehyde cross-linking yenziwa ku-solvent ephilayo eyakhiwe nge-ethanol engu-75% + 5% octanol. Le ndlela isiza ukususa ngokuphumelelayo ama-phospholipids ezicubu ngesikhathi sokuxhumanisa-ama-phospholipids abe yizindawo eziyinhloko ze-nucleation zokubala.

Umenzeli Wokugcwalisa Isikhala:

Ngemuva kokuxhumanisa, i-polyethylene glycol (PEG) isetshenziswa njenge-ejenti yokugcwalisa isikhala, ingena izikhala phakathi kwe-collagen fibers. Lokhu kokubili kuvikela izindawo ze-nucleation zamakristalu e-hydroxyapatite futhi kuvimbele ukungena kwe-calcium ne-phospholipids ku-plasma ephethe.

Ukuvalwa kwetheminali:

Okokugcina, ukwelashwa nge-glycine kwenza amaqembu e-aldehyde yamahhala ayinsalela, angasebenzi, ngaleyo ndlela kuqedwe esinye isici esibalulekile esibangela ukubalwa kanye ne-cytotoxicity.

2. Imiphumela Emihle Yomtholampilo:

Lobu buchwepheshe busetshenziswe ku-scaffold ye-bovine pericardial ebizwa ngokuthi "Periborn." Ucwaningo lokulandelela emtholampilo oluhlanganisa iziguli ezingu-352 phakathi neminyaka engu-9 lubonise inkululeko ekusebenziseni kabusha ngenxa yezinkinga ezihlobene nomkhiqizo ezifinyelela ku-95.4%, okuqinisekisa ukusebenza kahle kwaleli su elisha lokulwa nokubala kanye nokuqina kwalo okukhethekile kwesikhathi eside.

Ukubaluleka kwalokhu kugqashuka:

Ayibheki nje kuphela inselele esinesikhathi eside emkhakheni wama-valve e-bioprosthetic, ukwandisa isikhathi sokuphila komkhiqizo, kodwa futhi ifaka ubungqabavu obusha ekusetshenzisweni kwe-glutaraldehyde ezintweni ezisezingeni eliphezulu ze-biomedical.