Impumelelo yesayensi esezingeni eliphezulu kubuchwepheshe obusezingeni eliphezulu bokudelela, obuthuthukiswe inkampani entsha yezinto zokwakha ezinze e-Heilongjiang, e-China, yashicilelwa ngokusemthethweni kujenali yezemfundo ephakeme yamazwe ngamazwe i-Nature ekuqaleni kuka-November 2025. Yamukelwa njengentuthuko esezingeni lomhlaba ekuhlanganiseni izidakamizwa kanye ne-R&D, le nqubo entsha idonsele ukunakwa okusabalele ngenxa yamandla ayo okuguqula kabusha ama-molecular modules amaningi.
Impumelelo eyinhloko ilele ekuthuthukisweni kwesu eliqondile lokususa i-deamination elilamula ukubunjwa kwe-N-nitroamine. Le ndlela yokuphayona inikeza indlela entsha yokuguqulwa okunembile kwamakhompiyutha e-heterocyclic kanye nokuphuma kwe-aniline-izici ezibalulekile zokwakha ekuthuthukisweni kwezidakamizwa kanye nokuhlanganiswa kwamakhemikhali amahle. Ngokungafani nezindlela zendabuko zokuqeda i-deamine ezivame ukuthembela kuma-intermediate angazinzile noma izimo zokusabela ezinzima, ubuchwepheshe be-N-nitroamine-mediated buhlinzeka ngokushintsha kwepharadigm ekusebenzeni kahle nokuguquguquka.
Izinzuzo ezintathu ezivelele zichaza le ndlela: yonke indawo, ukusebenza kahle okuphezulu, nokusebenza okulula. Ibonisa ukusebenza okubanzi kunhlobonhlobo yama-molecule aqondiwe, isusa imikhawulo yamasu avamile akhawulelwe isakhiwo se-substrate noma isikhundla seqembu le-amino. Ukusabela kuqhubeka ngaphansi kwezimo ezithambile, ukugwema isidingo sezisusa ezinobuthi noma izilawuli ezidlulele zokushisa/nokucindezela, okunciphisa kakhulu izingozi zokuphepha nomthelela wemvelo. Okuphawuleka kakhulu, ubuchwepheshe buqede ngempumelelo ukuqinisekiswa kokukhiqizwa komshayeli wesilinganiso sekhilogremu, okubonisa ukuthi kungenzeka yini ukusetshenziswa kwezimboni ezinkulu kanye nokubeka isisekelo esiqinile sokuhweba.
Inani lesicelo lalokhu kuqanjwa kwedlula kude kwezemithi. Kulindeleke ukuthi kutholwe ukutholwa okusabalele kubunjiniyela bamakhemikhali, izinto ezithuthukile, kanye nokuhlanganiswa kwezibulala-zinambuzane. Ekuthuthukisweni kwezidakamizwa, kuzokwenza lula ukukhiqizwa kweziphakathi ezibalulekile, kusheshiswe inqubo ye-R&D yezidakamizwa ezinama-molecule amancane njengama-anticancer agents kanye nemithi yezinzwa. Emikhakheni yamakhemikhali nezinto zokwakha, ivumela ukuhlanganiswa okuluhlaza futhi okungabizi kakhulu kwamakhemikhali akhethekile nezinto zokusebenza. Ekwenziweni kwezibulala-zinambuzane, kunikeza indlela esimeme kakhudlwana yokukhiqiza okuphakathi okusebenza okuphezulu kuyilapho kuthobela imithetho eqinile yezemvelo.
Lokhu kuphumelela akugcini nje ngokubhekana nezinselelo osekunesikhathi eside zikhona ekuguqulweni kwamangqamuzana kodwa futhi kuqinisa isikhundla seShayina ekusungulweni kwamakhemikhali okuphambili. Njengoba ukuthuthukiswa kwezimboni kuqhubeka, ubuchwepheshe bukulungele ukuthuthukisa izinzuzo ezisebenza kahle kanye nokwehliswa kwezindleko emikhakheni eminingi, okuphawula igxathu elibalulekile eliya phambili ekushintsheni emhlabeni jikelele ezindleleni zokukhiqiza eziluhlaza nezizinzile.
Isikhathi sokuthumela: Nov-14-2025