1. Ukusungula Izinto Ezintsha Kubuchwepheshe Bokuthola
Ukuthuthukiswa kwezindlela zokuthola ezinembile nezisebenzayo kusalokhu kuyindawo ebalulekile ocwaningweni lwe-sodium cyclamate, kudlala indima ebalulekile ekulawulweni kokuphepha kokudla.
Ukuthwebula Izithombe Nge-Hyperspectral Kuhlanganiswe Nokufunda Komshini:
Ucwaningo lwango-2025 lwethule indlela yokuthola ngokushesha futhi engonakalisi. Le ndlela isebenzisa i-near-infrared hyperspectral imaging (NIR-HSI, 1000–1700 nm) ukuskena impuphu yokudla kwekati futhi ifaka ama-chemometrics kanye nama-algorithms okufunda komshini (isb., amamodeli e-partial least squares regression (PLSR) acutshungulwe ngaphambilini nge-Savitzky–Golay smoothing) ukuze kufezwe ukuhlaziywa kwenani le-sodium saccharin engezwe ngokungemthetho kanye nezinye izinto ezinambithekayo. Kubikwa ukuthi imodeli ithole i-predictive coefficient of determination (R²) ephezulu njenge-0.98 kanye ne-root mean square error of prediction (RMSEP) engu-0.22 wt%. Lokhu kunikeza ithuluzi elisha elinamandla lokuqapha ikhwalithi yokudla kwezilwane ezifuywayo kanye nezinye izinhlobo zokudla eziyinkimbinkimbi.
Ukuhlanganiswa Kwezindinganiso Zangaphakathi Ezine-Isotope Eziqinile:
Ukuze kuthuthukiswe ukunemba kanye nokumelana nokuphazamiseka kokutholwa kwe-mass spectrometric, abacwaningi bahlanganise i-deuterium-labeled sodium cyclamate (i-sodium cyclamate eqinisiwe ene-D) njengendinganiso yangaphakathi. Ukuhlanganiswa kwaqala ngamanzi asindayo (D₂O) kanye ne-cyclohexanone, kuqhubeka nge-base-catalyzed hydrogen-deuterium exchange, i-reductive amination, kanye nezinyathelo ze-sulfonylation ukuze ekugcineni kukhiqizwe i-tetradeutero sodium cyclohexylsulfamate enobuningi be-deuterium isotope obudlula u-99%. Uma kusetshenziswa kanye ne-isotope dilution mass spectrometry (ID-MS), amazinga anjalo angaphakathi athuthukisa kakhulu ukunemba nokuthembeka kokutholwa, ikakhulukazi ukuqinisekisa kanye nokulinganisa okunembile kwamazinga okulandelela e-sodium cyclamate kumasampula ayinkimbinkimbi.
2. Ukuhlolwa kabusha kwemiphumela yokuphepha kanye nezempilo
Ukuphepha kwe-sodium cyclamate kuyaqhubeka nokuba yinto ebalulekile kwezesayensi nasemphakathini, njengoba izifundo ezintsha ziqhubeka nokuhlola imiphumela yayo engaba khona empilweni.
Imithethonqubo kanye Nokusetshenziswa Kwamanje:
Kubalulekile ukuqaphela ukuthi imithetho elawula i-sodium cyclamate ayihlanganisiwe emhlabeni jikelele. Ukusetshenziswa kwayo njengesithako sokudla akuvunyelwe emazweni afana ne-United States, i-United Kingdom, ne-Japan. Kodwa-ke, kuvunyelwe emazweni afana ne-China, yize kunemikhawulo eqinile (isb., GB2760-2011). Le mikhawulo isungulwa ngokusekelwe ekuhlolweni kokuphepha okukhona.
Ukukhathazeka Ngokuphathelene Nezingozi Zempilo Ezingaba Khona:
Nakuba imiphumela yokusesha ingazange iveze okutholakele okusha okukhulu ngo-2025 mayelana nezingozi zempilo eziqondene ne-sodium cyclamate uqobo, ucwaningo olwenziwe kwesinye isithasiselo sokwenziwa, i-sodium saccharin, luyaphawuleka. Kusetshenziswa imodeli yegundane ebangelwa yi-letrozole ye-polycystic ovary syndrome (PCOS), ucwaningo luthole ukuthi i-sodium saccharin ingase ibhebhethekise ukukhubazeka okuhlobene ne-PCOS (isb., ukuncipha kwamaseli angaphandle e-granulosa, ukwanda kwama-cyst) kanye nezinkinga ze-endocrine ngokusebenzisa ama-receptors okunambitheka okumnandi nokubabayo kuma-ovari, okuphazamisa izici ze-steroidogenic (njenge-StAR, i-CYP11A1, i-17β-HSD), kanye nokusebenzisa indlela ye-p38-MAPK/ERK1/2 apoptosis. Lolu cwaningo lusebenza njengesikhumbuzo sokuthi imiphumela engaba khona yezempilo yama-sweeteners okwenziwa, ikakhulukazi ekusetshenzisweni isikhathi eside kanye nomthelela wawo kubantu abathile abazwelayo, idinga ukunakwa okuqhubekayo kanye nocwaningo olujulile.
3. Izitayela Zemakethe Neziqondiso Zesikhathi Esizayo
Imakethe kanye nentuthuko ye-sodium cyclamate nakho kubonisa ukuthambekela okuthile.
Okuqhutshwa Yisidingo Semakethe:
Imakethe yoswidi wokwenziwa, okuhlanganisa ne-sodium cyclamate, iqhutshwa ngokwengxenye yisidingo somhlaba wonke esivela ezimbonini zokudla, iziphuzo, kanye nemithi yoswidi olunamakhalori aphansi futhi olungabizi kakhulu. Ikakhulukazi kwamanye amazwe asathuthuka, i-sodium cyclamate isasetshenziswa ngenxa yentengo yayo ephansi kanye nobukhali bayo obukhulu (cishe izikhathi ezingu-30-40 ezimnandi kune-sucrose).
Izitayela Zentuthuko Yesikhathi Esizayo:
Ibhekene nezinselele, imboni ye-sodium cyclamate ingase igxile kakhulu ekuthuthukisweni okugxile empilweni. Lokhu kungafaka phakathi ukuhlola ukuthuthukiswa kwesakhiwo sama-molecule kanye nokwakheka kwawo ukuze kuthuthukiswe ukuhambisana kwayo kanye nephrofayili yokunambitha, okwenza kube seduze noshukela wemvelo. Ngesikhathi esifanayo, ukuhlanganisa umqondo wokudla okunembile ukuthuthukisa imikhiqizo eyenziwe ngokwezifiso ehlangabezana nezidingo ezithile zezempilo (isb., ukuphathwa kwesifo sikashukela) nakho kuyindlela engaba khona.
Sekukonke, inqubekela phambili yakamuva yocwaningo nge-sodium cyclamate ikhombisa izici ezimbili eziyinhloko:
Ngakolunye uhlangothi, ubuchwepheshe bokuthola buqhubekela phambili ngesivinini esikhulu, ukunemba, kanye nomphumela ophezulu. Ubuchwepheshe obusha, njengokuhlanganiswa kwe-hyperspectral imaging kanye nokufunda komshini kanye nokusetshenziswa kwezindinganiso zangaphakathi ze-isotope ezizinzile, buhlinzeka ngamathuluzi anamandla kakhulu okulawula ukuphepha kokudla.
Ngakolunye uhlangothi, ukukhathazeka mayelana nemiphumela yayo empilweni kusaqhubeka. Nakuba idatha yakamuva yobuthi ikakhulukazi kwi-sodium cyclamate ngokwayo ilinganiselwe, izifundo eziphathelene noshukela wokwenziwa ohlobene (isb. i-sodium saccharin) ziphakamisa ukuthi ukunaka okuqhubekayo emiphumeleni yabo yempilo yesikhathi eside kuyadingeka.
Isikhathi sokuthunyelwe: Septhemba 15-2025